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Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase

DNA methyltransferases interact with their CpG target sites in the context of variable flanking sequences. We investigated DNA methylation by the human DNMT3B catalytic domain using substrate pools containing CpX target sites in randomized flanking context and identified combined effects of CpG reco...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Dukatz, Michael, Adam, Sabrina, Biswal, Mahamaya, Song, Jikui, Bashtrykov, Pavel, Jeltsch, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7672481/
https://ncbi.nlm.nih.gov/pubmed/33105482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa938
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