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Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
Smoothened (SMO), a class-Frizzled G protein-coupled receptor (class-F GPCR), transduces the Hedgehog signal across cell membrane. Sterols can bind to its extracellular cysteine rich domain (CRD) and to several sites in the 7 transmembrane helices (7-TMs) of SMO. However, the mechanism how sterols r...
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| Pubblicato in: | Nat Chem Biol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7669734/ https://ncbi.nlm.nih.gov/pubmed/32929279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0646-2 |
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