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Regulation of Smoothened trafficking and Hedgehog signaling by the SUMO pathway
Hedgehog (Hh) signaling plays a central role in development and diseases. Hh activates its signal transducer and GPCR-family protein Smoothened (Smo) by inducing Smo phosphorylation but whether Smo is activated through other post-translational modifications remains unexplored. Here we show that sumo...
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| Veröffentlicht in: | Dev Cell |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5121078/ https://ncbi.nlm.nih.gov/pubmed/27746045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2016.09.014 |
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