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Regulation of Smoothened trafficking and Hedgehog signaling by the SUMO pathway

Hedgehog (Hh) signaling plays a central role in development and diseases. Hh activates its signal transducer and GPCR-family protein Smoothened (Smo) by inducing Smo phosphorylation but whether Smo is activated through other post-translational modifications remains unexplored. Here we show that sumo...

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Bibliografiske detaljer
Udgivet i:Dev Cell
Main Authors: Ma, Guoqiang, Li, Shuang, Han, Yuhong, Li, Shuangxi, Yue, Tao, Wang, Bing, Jiang, Jin
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121078/
https://ncbi.nlm.nih.gov/pubmed/27746045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2016.09.014
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