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Intrathecal Administration of Resolvin D1 and E1 Decreases Hyperalgesia in Mice with Bone Cancer Pain: Involvement of Endocannabinoid Signaling

Pain produced by bone cancer is often severe and difficult to treat. Here we examined effects of Resolvin D1 (RvD1) or E1 (RvE1), antinociceptive products of ω−3 polyunsaturated fatty acids, on cancer-induced mechanical allodynia and heat hyperalgesia. Experiments were performed using a mouse model...

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Detalhes bibliográficos
Publicado no:Prostaglandins Other Lipid Mediat
Main Authors: Khasabova, Iryna A., Golovko, Mikhail Y., Golovko, Svetlana A., Simone, Donald A., Khasabov, Sergey G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7669692/
https://ncbi.nlm.nih.gov/pubmed/32745525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.prostaglandins.2020.106479
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