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Hyperalgesia and sensitization of dorsal horn neurons following activation of NK-1 receptors in the rostral ventromedial medulla

Neurons in the rostral ventromedial medulla (RVM) project to the spinal cord and are involved in descending modulation of pain. Several studies have shown that activation of neurokinin-1 (NK-1) receptors in the RVM produces hyperalgesia, although the underlying mechanisms are not clear. In parallel...

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Bibliografiske detaljer
Udgivet i:J Neurophysiol
Main Authors: Khasabov, Sergey G., Malecha, Patrick, Noack, Joseph, Tabakov, Janneta, Giesler, Glenn J., Simone, Donald A.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675905/
https://ncbi.nlm.nih.gov/pubmed/28794197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00478.2017
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