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Hyperalgesia and sensitization of dorsal horn neurons following activation of NK-1 receptors in the rostral ventromedial medulla

Neurons in the rostral ventromedial medulla (RVM) project to the spinal cord and are involved in descending modulation of pain. Several studies have shown that activation of neurokinin-1 (NK-1) receptors in the RVM produces hyperalgesia, although the underlying mechanisms are not clear. In parallel...

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Pubblicato in:J Neurophysiol
Autori principali: Khasabov, Sergey G., Malecha, Patrick, Noack, Joseph, Tabakov, Janneta, Giesler, Glenn J., Simone, Donald A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675905/
https://ncbi.nlm.nih.gov/pubmed/28794197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00478.2017
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