Sensitization of nociceptors by prostaglandin E(2)–glycerol contributes to hyperalgesia in mice with sickle cell disease

Pain is a characteristic feature of sickle cell disease (SCD), 1 of the most common inherited diseases. Patients may experience acute painful crises as well as chronic pain. In the Berkley transgenic murine model of SCD, HbSS-BERK mice express only human hemoglobin S. These mice share many features...

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Bibliographic Details
Published in:Blood
Main Authors: Khasabova, Iryna A., Uhelski, Megan, Khasabov, Sergey G., Gupta, Kalpna, Seybold, Virginia S., Simone, Donald A.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2019
Subjects:
Red Cells, Iron, and Erythropoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497514/
https://ncbi.nlm.nih.gov/pubmed/30796025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-11-884346
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