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Sensitization of C-fiber nociceptors in mice with sickle cell disease is decreased by local inhibition of anandamide hydrolysis

Sickle cell disease (SCD) is accompanied by chronic pain that is difficult to treat. There is evidence that increasing levels of endocannabinoids in the periphery can modulate pain by decreasing excitability of nociceptors. Using a humanized mouse model of SCD, we show that blocking hydrolysis of th...

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Опубликовано в: :Pain
Главные авторы: Uhelski, Megan L., Gupta, Kalpna, Simone, Donald A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561456/
https://ncbi.nlm.nih.gov/pubmed/28570479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000966
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