Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids

Sickle cell disease causes severe pain. We examined pain-related behaviors, correlative neurochemical changes, and analgesic effects of morphine and cannabinoids in transgenic mice expressing human sickle hemoglobin (HbS). Paw withdrawal threshold and withdrawal latency (to mechanical and thermal st...

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Detalhes bibliográficos
Main Authors: Kohli, Divyanshoo R., Li, Yunfang, Khasabov, Sergey G., Gupta, Pankaj, Kehl, Lois J., Ericson, Marna E., Nguyen, Julia, Gupta, Vinita, Hebbel, Robert P., Simone, Donald A., Gupta, Kalpna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913454/
https://ncbi.nlm.nih.gov/pubmed/20304807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-260372
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