g(HbF): a genetic model of fetal hemoglobin in sickle cell disease

Fetal hemoglobin (HbF) is a strong modifier of sickle cell disease (SCD) severity and is associated with 3 common genetic loci. Quantifying the genetic effects of the 3 loci would specifically address the benefits of HbF increases in patients. Here, we have applied statistical methods using the most...

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Bibliographic Details
Published in:Blood Adv
Main Authors: Gardner, Kate, Fulford, Tony, Silver, Nicholas, Rooks, Helen, Angelis, Nikolaos, Allman, Marlene, Nkya, Siana, Makani, Julie, Howard, Jo, Kesse-Adu, Rachel, Rees, David C., Stuart-Smith, Sara, Yeghen, Tullie, Awogbade, Moji, Sangeda, Raphael Z., Mgaya, Josephine, Patel, Hamel, Newhouse, Stephen, Menzel, Stephan, Thein, Swee Lay
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2018
Subjects:
Red Cells, Iron, and Erythropoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812320/
https://ncbi.nlm.nih.gov/pubmed/29437638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017009811
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