Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia

Fetal hemoglobin (HbF, α(2)γ(2)) is a major contributor to the remarkable phenotypic heterogeneity of sickle cell anemia (SCA). Genetic variation at 3 principal loci (HBB cluster on chromosome 11p, HBS1L-MYB region on chromosome 6q, and BCL11A on chromosome 2p) have been shown to influence HbF level...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Makani, Julie, Menzel, Stephan, Nkya, Siana, Cox, Sharon E., Drasar, Emma, Soka, Deogratius, Komba, Albert N., Mgaya, Josephine, Rooks, Helen, Vasavda, Nisha, Fegan, Gregory, Newton, Charles R., Farrall, Martin, Thein, Swee Lay
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555384/
https://ncbi.nlm.nih.gov/pubmed/21068433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-302703
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