Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer

BACKGROUND: Common genetic variants residing near upstream regulatory elements for MYB, the gene encoding transcription factor cMYB, promote the persistence of fetal hemoglobin (HbF) into adulthood. While they have no consequences in healthy individuals, high HbF levels have major clinical benefits...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:BMC Med Genet
Asıl Yazarlar: Mtatiro, Siana N, Mgaya, Josephine, Singh, Tarjinder, Mariki, Harvest, Rooks, Helen, Soka, Deogratius, Mmbando, Bruno, Thein, Swee Lay, Barrett, Jeffrey C, Makani, Julie, Cox, Sharon E, Menzel, Stephan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422446/
https://ncbi.nlm.nih.gov/pubmed/25928412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12881-015-0148-3
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller