Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer

BACKGROUND: Common genetic variants residing near upstream regulatory elements for MYB, the gene encoding transcription factor cMYB, promote the persistence of fetal hemoglobin (HbF) into adulthood. While they have no consequences in healthy individuals, high HbF levels have major clinical benefits...

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Udgivet i:BMC Med Genet
Main Authors: Mtatiro, Siana N, Mgaya, Josephine, Singh, Tarjinder, Mariki, Harvest, Rooks, Helen, Soka, Deogratius, Mmbando, Bruno, Thein, Swee Lay, Barrett, Jeffrey C, Makani, Julie, Cox, Sharon E, Menzel, Stephan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422446/
https://ncbi.nlm.nih.gov/pubmed/25928412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12881-015-0148-3
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