Genetic variants at HbF‐modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania

Fetal hemoglobin (HbF) is a recognized modulator of sickle cell disease (SCD) severity. HbF levels are strongly influenced by genetic variants at three major genetic loci, Xmn1‐HBG2, HMIP‐2, and BCL11A, but the effect of these loci on the hematological phenotype in SCD, has so far not been investiga...

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Udgivet i:Am J Hematol
Main Authors: Mtatiro, Siana Nkya, Makani, Julie, Mmbando, Bruno, Thein, Swee Lay, Menzel, Stephan, Cox, Sharon E.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2014
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E‐ONLY Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737118/
https://ncbi.nlm.nih.gov/pubmed/25263325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.23859
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