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Genetic variants at HbF‐modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania
Fetal hemoglobin (HbF) is a recognized modulator of sickle cell disease (SCD) severity. HbF levels are strongly influenced by genetic variants at three major genetic loci, Xmn1‐HBG2, HMIP‐2, and BCL11A, but the effect of these loci on the hematological phenotype in SCD, has so far not been investiga...
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| Pubblicato in: | Am J Hematol |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4737118/ https://ncbi.nlm.nih.gov/pubmed/25263325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.23859 |
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