Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer

BACKGROUND: Common genetic variants residing near upstream regulatory elements for MYB, the gene encoding transcription factor cMYB, promote the persistence of fetal hemoglobin (HbF) into adulthood. While they have no consequences in healthy individuals, high HbF levels have major clinical benefits...

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Vydáno v:BMC Med Genet
Hlavní autoři: Mtatiro, Siana N, Mgaya, Josephine, Singh, Tarjinder, Mariki, Harvest, Rooks, Helen, Soka, Deogratius, Mmbando, Bruno, Thein, Swee Lay, Barrett, Jeffrey C, Makani, Julie, Cox, Sharon E, Menzel, Stephan
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422446/
https://ncbi.nlm.nih.gov/pubmed/25928412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12881-015-0148-3
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