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Synthesis of 7-trifluoromethyl-7-deazapurine ribonucleoside analogs and their monophosphate prodrugs

Novel 7-trifluoromethyl-7-deazapurine ribonucleoside analogs (13a-c) and their Protides (15a-c) were successfully synthesized from ribolactol or 1-α-bromo-ribose derivatives using Silyl-Hilbert-Johnson or nucleobase-anion substitution reactions followed by key aromatic trifluoromethyl substitution....

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Bibliografski detalji
Izdano u:Nucleosides Nucleotides Nucleic Acids
Glavni autori: Cho, Jong Hyun, Bassit, Leda C., Amblard, Franck, Schinazi, Raymond F.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7668401/
https://ncbi.nlm.nih.gov/pubmed/31588837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770.2019.1674333
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