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Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs

Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy have been treated with one or more of these analogs. This review focuses on the chemical synthesis and biology of anticancer...

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Bibliographic Details
Published in:Chem Rev
Main Authors: Shelton, Jadd, Lu, Xiao, Hollenbaugh, Joseph A., Cho, Jong Hyun, Amblard, Franck, Schinazi, Raymond F.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717319/
https://ncbi.nlm.nih.gov/pubmed/27960273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrev.6b00209
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