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Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases
New carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases were synthesized and evaluated as potential anti-HIV and anti-HCV agents. Among the synthesized carbocyclic nucleoside analogs, the pyrazole amide 15f exhibited modest selective anti-HIV-1 activity (EC(50) = 24 µM).
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| Publicado no: | Tetrahedron Lett |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4446795/ https://ncbi.nlm.nih.gov/pubmed/26028788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2015.01.051 |
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