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Synthesis of Cyclopentanyl Carbocyclic 5-Fluorocytosine ((−)-5-Fluoro-Carbodine) Using a Facially Selective Hydrogenation Approach

[Image: see text] An efficient synthetic route to biologically relevant (−)-5-fluorocarbodine 6 was developed. Direct coupling of N(6) protected 5-fluorouracil 15 with cyclopentenyl intermediate 13, followed by formation of a macrocycle between the base and the carbocyclic sugar moiety, via ring clo...

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Detalhes bibliográficos
Main Authors: Cho, Jong Hyun, Amblard, Franck, Coats, Steven J., Schinazi, Raymond F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569026/
https://ncbi.nlm.nih.gov/pubmed/23231055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo302038d
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