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Synthesis of Cyclopentanyl Carbocyclic 5-Fluorocytosine ((−)-5-Fluoro-Carbodine) Using a Facially Selective Hydrogenation Approach
[Image: see text] An efficient synthetic route to biologically relevant (−)-5-fluorocarbodine 6 was developed. Direct coupling of N(6) protected 5-fluorouracil 15 with cyclopentenyl intermediate 13, followed by formation of a macrocycle between the base and the carbocyclic sugar moiety, via ring clo...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3569026/ https://ncbi.nlm.nih.gov/pubmed/23231055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo302038d |
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