A native function for RAN translation and CGG repeats in regulating Fragile X protein synthesis

Repeat-associated non-AUG translation of expanded CGG repeats (CGG RAN) from the FMR1 5’ UTR produces toxic proteins that contribute to neurodegeneration in Fragile X-associated Tremor/Ataxia Syndrome (FXTAS). Here we describe how unexpanded CGG repeats and their translation play conserved roles in...

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Detaylı Bibliyografya
Yayımlandı:Nat Neurosci
Asıl Yazarlar: Rodriguez, Caitlin M., Wright, Shannon E., Kearse, Michael G., Haenfler, Jill M., Flores, Brittany N., Liu, Yu, Ifrim, Marius F., Glineburg, Mary R., Krans, Amy, Jafar-Nejad, Paymaan, Sutton, Michael A., Bassell, Gary J., Parent, Jack M., Rigo, Frank, Barmada, Sami J., Todd, Peter K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7668390/
https://ncbi.nlm.nih.gov/pubmed/32066985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-020-0590-1
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