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RAN translation from antisense CCG repeats in Fragile X Tremor/Ataxia Syndrome

OBJECTIVE: Repeat associated non-AUG (RAN) translation drives production of toxic proteins from pathogenic repeat sequences in multiple untreatable neurodegenerative disorders. Fragile X-associated tremor/ataxia syndrome (FXTAS) is one such condition, resulting from a CGG trinucleotide repeat expans...

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Bibliografski detalji
Izdano u:Ann Neurol
Glavni autori: Krans, Amy, Kearse, Michael G., Todd, Peter K.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5177492/
https://ncbi.nlm.nih.gov/pubmed/27761921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24800
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