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2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2.: Part 1: Identification of an allosteric binding site
CK2 is a ubiquitous Ser/Thr protein kinase involved in the control of various signaling pathways and is known to be constitutively active. In the present study, we identified aryl 2-aminothiazoles as a novel class of CK2 inhibitors, which displayed a non ATP-competitive mode of action and stabilized...
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| Publicado no: | J Med Chem |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7667462/ https://ncbi.nlm.nih.gov/pubmed/30689953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01766 |
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