2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 2: Structure–based optimization and investigation of effects specific to the allosteric mode of action

Protein CK2 has gained much interest as an anti-cancer drug target in the last decade. We had previously described the identification of a new allosteric site on the catalytic α-subunit, along with first small molecule ligands based on the 4-(4-phenylthiazol-2-ylamino) benzoic acid scaffold. In the...

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Bibliographic Details
Published in:J Med Chem
Main Authors: Bestgen, Benoît, Kufareva, Irina, Seetoh, Weiguang, Abell, Chris, Hartmann, Rolf W., Abagyan, Ruben, Borgne, Marc Le, Filhol, Odile, Cochet, Claude, Lomberget, Thierry, Engel, Matthias
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7579840/
https://ncbi.nlm.nih.gov/pubmed/30689946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01765
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