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In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface

Protein kinase CK2 is a tetrameric holoenzyme composed of two catalytic (α and/or α’) subunits and two regulatory (β) subunits. Crystallographic data paired with fluorescence imaging techniques have suggested that the formation of the CK2 holoenzyme complex within cells is a dynamic process. Althoug...

詳細記述

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書誌詳細
出版年:Pharmaceuticals (Basel)
主要な著者: Bestgen, Benoît, Belaid-Choucair, Zakia, Lomberget, Thierry, Le Borgne, Marc, Filhol, Odile, Cochet, Claude
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374420/
https://ncbi.nlm.nih.gov/pubmed/28165359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph10010016
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