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Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors
CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interface has been previously targeted by peptides to achieve functional effects; however, no small molecules modulat...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6828666/ https://ncbi.nlm.nih.gov/pubmed/31685885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52141-5 |
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