Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors

CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interface has been previously targeted by peptides to achieve functional effects; however, no small molecules modulat...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Kufareva, Irina, Bestgen, Benoit, Brear, Paul, Prudent, Renaud, Laudet, Béatrice, Moucadel, Virginie, Ettaoussi, Mohamed, Sautel, Celine F., Krimm, Isabelle, Engel, Matthias, Filhol, Odile, Borgne, Marc Le, Lomberget, Thierry, Cochet, Claude, Abagyan, Ruben
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6828666/
https://ncbi.nlm.nih.gov/pubmed/31685885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52141-5
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