Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations

Parkin (encoded by PRKN) is a ubiquitin ligase that plays an important role in cellular mitochondrial quality control. Mutations in PRKN cause selective dopaminergic cell loss in the substantia nigra and are presumed to induce a decrease in mitochondrial function caused by the defective clearance of...

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發表在:NPJ Parkinsons Dis
Main Authors: Kano, Masayoshi, Takanashi, Masashi, Oyama, Genko, Yoritaka, Asako, Hatano, Taku, Shiba-Fukushima, Kahori, Nagai, Makiko, Nishiyama, Kazutoshi, Hasegawa, Kazuko, Inoshita, Tsuyoshi, Ishikawa, Kei-ichi, Akamatsu, Wado, Imai, Yuzuru, Bolognin, Silvia, Schwamborn, Jens Christian, Hattori, Nobutaka
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7666226/
https://ncbi.nlm.nih.gov/pubmed/33298969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41531-020-00137-8
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