Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations

Parkin (encoded by PRKN) is a ubiquitin ligase that plays an important role in cellular mitochondrial quality control. Mutations in PRKN cause selective dopaminergic cell loss in the substantia nigra and are presumed to induce a decrease in mitochondrial function caused by the defective clearance of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:NPJ Parkinsons Dis
Main Authors: Kano, Masayoshi, Takanashi, Masashi, Oyama, Genko, Yoritaka, Asako, Hatano, Taku, Shiba-Fukushima, Kahori, Nagai, Makiko, Nishiyama, Kazutoshi, Hasegawa, Kazuko, Inoshita, Tsuyoshi, Ishikawa, Kei-ichi, Akamatsu, Wado, Imai, Yuzuru, Bolognin, Silvia, Schwamborn, Jens Christian, Hattori, Nobutaka
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7666226/
https://ncbi.nlm.nih.gov/pubmed/33298969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41531-020-00137-8
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados