An Ancient CFTR Ortholog Informs Molecular Evolution in ABC Transporters

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride channel central to the development of secretory diarrhea and cystic fibrosis. The oldest CFTR ortholog identified is from dogfish shark which retains similar structural and functional characteristics to the mammalian protei...

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Publicado no:Dev Cell
Main Authors: Cui, Guiying, Hong, Jeong, Chung-Davidson, Yu-Wen, Infield, Daniel, Xu, Xin, Li, Jindong, Simhaev, Luba, Khazanov, Netaly, Stauffer, Brandon, Imhoff, Barry, Cottrill, Kirsten, Blalock, J. Edwin, Li, Weiming, Senderowitz, Hanoch, Sorscher, Eric, McCarty, Nael, Gaggar, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7665244/
https://ncbi.nlm.nih.gov/pubmed/31679858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.09.017
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