Potentiators exert distinct effects on human, murine, and Xenopus CFTR

VX-770 (Ivacaftor) has been approved for clinical usage in cystic fibrosis patients with several CFTR mutations. Yet the binding site(s) on CFTR for this compound and other small molecule potentiators are unknown. We hypothesize that insight into this question could be gained by comparing the effect...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Cui, Guiying, Khazanov, Netaly, Stauffer, Brandon B., Infield, Daniel T., Imhoff, Barry R., Senderowitz, Hanoch, McCarty, Nael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
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Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142458/
https://ncbi.nlm.nih.gov/pubmed/27288484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00056.2016
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