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Murine and human CFTR exhibit different sensitivities to CFTR potentiators
Development of therapeutic molecules with clinical efficacy as modulators of defective CFTR includes efforts to identify potentiators that can overcome or repair the gating defect in mutant CFTR channels. This has taken a great leap forward with the identification of the potentiator VX-770, now avai...
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| Udgivet i: | Am J Physiol Lung Cell Mol Physiol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4593837/ https://ncbi.nlm.nih.gov/pubmed/26209275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00181.2015 |
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