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Murine and human CFTR exhibit different sensitivities to CFTR potentiators

Development of therapeutic molecules with clinical efficacy as modulators of defective CFTR includes efforts to identify potentiators that can overcome or repair the gating defect in mutant CFTR channels. This has taken a great leap forward with the identification of the potentiator VX-770, now avai...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Physiol Lung Cell Mol Physiol
Prif Awduron: Cui, Guiying, McCarty, Nael A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593837/
https://ncbi.nlm.nih.gov/pubmed/26209275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00181.2015
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