Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity

The Mus81-Mms4 nuclease is activated in G2/M via Mms4 phosphorylation to allow resolution of persistent recombination structures. However, the fate of the activated phosphorylated Mms4 remains unknown. Here we find that Mms4 is engaged by (poly)SUMOylation and ubiquitylation and targeted for proteas...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Waizenegger, Anja, Urulangodi, Madhusoodanan, Lehmann, Carl P., Reyes, Teresa Anne Clarisse, Saugar, Irene, Tercero, José Antonio, Szakal, Barnabas, Branzei, Dana
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7665200/
https://ncbi.nlm.nih.gov/pubmed/33184279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19503-4
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker