Cell cycle-dependent regulation of the nuclease activity of Mus81–Eme1/Mms4

The conserved heterodimeric endonuclease Mus81–Eme1/Mms4 plays an important role in the maintenance of genomic integrity in eukaryotic cells. Here, we show that budding yeast Mus81–Mms4 is strictly regulated during the mitotic cell cycle by Cdc28 (CDK)- and Cdc5 (Polo-like kinase)-dependent phosphor...

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Autores principales: Gallo-Fernández, María, Saugar, Irene, Ortiz-Bazán, María Ángeles, Vázquez, María Victoria, Tercero, José Antonio
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458551/
https://ncbi.nlm.nih.gov/pubmed/22730299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks599
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