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Mimicking the Nucleosomal Context in Peptide-Based Binders of a H3K36me Reader Increases Binding Affinity While Altering the Binding Mode

Targeting of proteins in the histone modification machinery has emerged as a promising new direction to fight disease. The search for compounds that inhibit proteins that readout histone modification has led to several new epigenetic drugs, mostly for proteins involved in recognition of acetylated l...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Horn, Velten, Jongkees, Seino A. K., van Ingen, Hugo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7662849/
https://ncbi.nlm.nih.gov/pubmed/33114657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25214951
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