Binding of PHF1 Tudor to H3K36me3 enhances nucleosome accessibility

The Tudor domain of human PHF1 recognizes trimethylated lysine 36 of histone H3 (H3K36me3). This interaction modulates methyltransferase activity of the PRC2 complex and plays a role in retention of PHF1 at the DNA damage sites. We have previously determined the structural basis for the association...

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Autors principals: Musselman, Catherine A., Gibson, Matthew D., Hartwick, Erik W., North, Justin A., Gatchalian, Jovylyn, Poirier, Michael G., Kutateladze, Tatiana G.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007151/
https://ncbi.nlm.nih.gov/pubmed/24352064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3969
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