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Binding of PHF1 Tudor to H3K36me3 enhances nucleosome accessibility

The Tudor domain of human PHF1 recognizes trimethylated lysine 36 of histone H3 (H3K36me3). This interaction modulates methyltransferase activity of the PRC2 complex and plays a role in retention of PHF1 at the DNA damage sites. We have previously determined the structural basis for the association...

詳細記述

保存先:
書誌詳細
主要な著者: Musselman, Catherine A., Gibson, Matthew D., Hartwick, Erik W., North, Justin A., Gatchalian, Jovylyn, Poirier, Michael G., Kutateladze, Tatiana G.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007151/
https://ncbi.nlm.nih.gov/pubmed/24352064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3969
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