Binding of PHF1 Tudor to H3K36me3 enhances nucleosome accessibility

The Tudor domain of human PHF1 recognizes trimethylated lysine 36 of histone H3 (H3K36me3). This interaction modulates methyltransferase activity of the PRC2 complex and plays a role in retention of PHF1 at the DNA damage sites. We have previously determined the structural basis for the association...

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Bibliografische gegevens
Hoofdauteurs: Musselman, Catherine A., Gibson, Matthew D., Hartwick, Erik W., North, Justin A., Gatchalian, Jovylyn, Poirier, Michael G., Kutateladze, Tatiana G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007151/
https://ncbi.nlm.nih.gov/pubmed/24352064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3969
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