Osteoprotegerin Prevents Intracranial Aneurysm Progression by Promoting Collagen Biosynthesis and Vascular Smooth Muscle Cell Proliferation

BACKGROUND: Decreased extracellular matrix formation and few vascular smooth muscle cells (VSMCs) in cerebral vascular walls are the main characteristics of intracranial aneurysm (IA) pathogenesis. Recently, osteoprotegerin was reported to activate collagen biosynthesis and VSMC proliferation via th...

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Détails bibliographiques
Publié dans:J Am Heart Assoc
Auteurs principaux: Miyata, Takeshi, Minami, Manabu, Kataoka, Hiroharu, Hayashi, Kosuke, Ikedo, Taichi, Yang, Tao, Yamamoto, Yu, Yokode, Masayuki, Miyamoto, Susumu
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660769/
https://ncbi.nlm.nih.gov/pubmed/32856519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015731
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