Osteoprotegerin Prevents Intracranial Aneurysm Progression by Promoting Collagen Biosynthesis and Vascular Smooth Muscle Cell Proliferation

BACKGROUND: Decreased extracellular matrix formation and few vascular smooth muscle cells (VSMCs) in cerebral vascular walls are the main characteristics of intracranial aneurysm (IA) pathogenesis. Recently, osteoprotegerin was reported to activate collagen biosynthesis and VSMC proliferation via th...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Miyata, Takeshi, Minami, Manabu, Kataoka, Hiroharu, Hayashi, Kosuke, Ikedo, Taichi, Yang, Tao, Yamamoto, Yu, Yokode, Masayuki, Miyamoto, Susumu
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660769/
https://ncbi.nlm.nih.gov/pubmed/32856519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015731
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