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Osteoprotegerin Prevents Intracranial Aneurysm Progression by Promoting Collagen Biosynthesis and Vascular Smooth Muscle Cell Proliferation

BACKGROUND: Decreased extracellular matrix formation and few vascular smooth muscle cells (VSMCs) in cerebral vascular walls are the main characteristics of intracranial aneurysm (IA) pathogenesis. Recently, osteoprotegerin was reported to activate collagen biosynthesis and VSMC proliferation via th...

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Publicado en:J Am Heart Assoc
Autores principales: Miyata, Takeshi, Minami, Manabu, Kataoka, Hiroharu, Hayashi, Kosuke, Ikedo, Taichi, Yang, Tao, Yamamoto, Yu, Yokode, Masayuki, Miyamoto, Susumu
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660769/
https://ncbi.nlm.nih.gov/pubmed/32856519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015731
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