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Hedgehog Gli3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence‐related genes

Hedgehog signal is re‐activated in several cancers. In this study, we examined the role of Gli3 on malignant phenotype of tumorigenicity for colorectal cancer and its relationship with p53, WNT and ERK/AKT signals. Gli3 expression was detected in HT29 and SW480 (p53‐mutant) cells, but not in DLD‐1 (...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Iwasaki, Hironori, Nakano, Kenji, Shinkai, Kentaro, Kunisawa, Yumi, Hirahashi, Minako, Oda, Yoshinao, Onishi, Hideya, Katano, Mitsuo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657255/
https://ncbi.nlm.nih.gov/pubmed/23176625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12073
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