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Hedgehog inhibitor decreases chemosensitivity to 5‐fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer
Pancreatic cancer is one of the deadliest types of cancer. Previously, we showed that hypoxia increases invasiveness through upregulation of Smoothened (Smo) transcription in pancreatic ductal adenocarcinoma (PDAC) cells. Here, we first evaluated whether hypoxia‐induced increase in Smo contributes t...
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| Publicado no: | Cancer Sci |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7659296/ https://ncbi.nlm.nih.gov/pubmed/22486854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2012.02297.x |
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