Hedgehog inhibitor decreases chemosensitivity to 5‐fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer

Pancreatic cancer is one of the deadliest types of cancer. Previously, we showed that hypoxia increases invasiveness through upregulation of Smoothened (Smo) transcription in pancreatic ductal adenocarcinoma (PDAC) cells. Here, we first evaluated whether hypoxia‐induced increase in Smo contributes t...

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Bibliografiska uppgifter
I publikationen:Cancer Sci
Huvudupphovsmän: Onishi, Hideya, Morifuji, Yoshihiro, Kai, Masaya, Suyama, Kumi, Iwasaki, Hironori, Katano, Mitsuo
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2012
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659296/
https://ncbi.nlm.nih.gov/pubmed/22486854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2012.02297.x
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