O-GlcNAcylation of GLI Transcription Factors in Hyperglycemic Conditions Augments Hedgehog activity: Hyperglycemic conditions upregulate GLI activity

Modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) promotes tumor cell survival, proliferation, epigenetic changes, angiogenesis, invasion, and metastasis. Here we demonstrate that in conditions of elevated glucose, there is increased expression of key drug resistance proteins (AB...

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Publicat a:Lab Invest
Autors principals: Das, Shamik, Bailey, Sarah K., Metge, Brandon J., Hanna, Ann, Hinshaw, Dominique C., Mota, Mateus, Forero-Torres, Andres, Chatham, John C., Samant, Rajeev S., Shevde, Lalita A.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857801/
https://ncbi.nlm.nih.gov/pubmed/30420690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-018-0122-8
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