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Ataxia–telangiectasia mutated kinase‐mediated upregulation of NKG2D ligands on leukemia cells by resveratrol results in enhanced natural killer cell susceptibility

The powerful activating receptor NKG2D is expressed by natural killer (NK) cells and promotes cytotoxic lysis of cancer cells expressing NKG2D ligands (NKG2D‐Ls). We report the effective induction of NKG2D‐Ls, achieved with the naturally occurring polyphenol resveratrol, in a broad range of leukemia...

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Publicat a:Cancer Sci
Autors principals: Luis Espinoza, J., Takami, Akiyoshi, Trung, Ly Q., Nakao, Shinji
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657230/
https://ncbi.nlm.nih.gov/pubmed/23445485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12141
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