Human microRNA-1245 down-regulates the NKG2D receptor in natural killer cells and impairs NKG2D-mediated functions

BACKGROUND: NKG2D is an activating receptor expressed by natural killer and T cells, which have crucial functions in tumor and microbial immunosurveillance. Several cytokines have been identified as modulators of NKG2D receptor expression. However, little is known about NKG2D gene regulation. In thi...

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Bibliografiska uppgifter
Huvudupphovsmän: Espinoza, J. Luis, Takami, Akiyoshi, Yoshioka, Katsuji, Nakata, Katsuya, Sato, Tokiharu, Kasahara, Yoshihito, Nakao, Shinji
Materialtyp: Artigo
Språk:Inglês
Publicerad: Ferrata Storti Foundation 2012
Ämnen:
Original Articles and Brief Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436229/
https://ncbi.nlm.nih.gov/pubmed/22491735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.058529
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