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Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)‐reactivating agents enhance efficacy of 5‐fluorouracil on human colon cancer cells

Chemotherapy for colorectal cancer has become more complicated and diversified with the appearance of molecular‐targeting agents. 5‐Fluorouracil (5‐FU) has been a mainstay of chemotherapy for colorectal cancer, but it is still unknown whether the combining of 5‐FU with novel molecular‐targeting agen...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Watanabe, Motoki, Sowa, Yoshihiro, Yogosawa, Mayumi, Sakai, Toshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657192/
https://ncbi.nlm.nih.gov/pubmed/23438367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12139
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