Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells

With increasing clinical demands for MEK inhibitors in cancer treatment, overcoming the resistance to MEK inhibitors is an urgent problem to be solved. Numerous reports have shown that MEK inhibition results in the activation of PI3K-Akt signaling, which may confer apoptotic resistance to MEK inhibi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Iizuka-Ohashi, Mahiro, Watanabe, Motoki, Sukeno, Mamiko, Morita, Mie, Hoang, Ngoc Thi Hong, Kuchimaru, Takahiro, Kizaka-Kondoh, Shinae, Sowa, Yoshihiro, Sakaguchi, Koichi, Taguchi, Tetsuya, Sakai, Toshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929411/
https://ncbi.nlm.nih.gov/pubmed/29731968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24696
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