Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2

A small molecule compound, JTP-74057/GSK1120212/trametinib, had been discovered as a very potent antiproliferative agent able to induce the accumulation of CDK inhibitor p15(INK4b). To conduct its drug development rationally as an anticancer agent, molecular targets of this compound were identified...

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Main Authors: Yoshida, Takayuki, Kakegawa, Junya, Yamaguchi, Takayuki, Hantani, Yoshiji, Okajima, Nobuyuki, Sakai, Toshiyuki, Watanabe, Yoshihiro, Nakamura, Motonao
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2012
主題:
Research Papers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681492/
https://ncbi.nlm.nih.gov/pubmed/23237773
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