Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2

A small molecule compound, JTP-74057/GSK1120212/trametinib, had been discovered as a very potent antiproliferative agent able to induce the accumulation of CDK inhibitor p15(INK4b). To conduct its drug development rationally as an anticancer agent, molecular targets of this compound were identified...

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Bibliografiska uppgifter
Huvudupphovsmän: Yoshida, Takayuki, Kakegawa, Junya, Yamaguchi, Takayuki, Hantani, Yoshiji, Okajima, Nobuyuki, Sakai, Toshiyuki, Watanabe, Yoshihiro, Nakamura, Motonao
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2012
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681492/
https://ncbi.nlm.nih.gov/pubmed/23237773
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