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Targeting alterations in the RAF-MEK pathway
The MAPK pathway is one of the most commonly mutated oncogenic pathways in cancer. While RAS mutations are the most frequent MAPK alterations, less frequent alterations in downstream components of the pathway, including the RAF and MEK genes, offer promising therapeutic opportunities. In addition to...
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| Vydáno v: | Cancer Discov |
|---|---|
| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6397699/ https://ncbi.nlm.nih.gov/pubmed/30770389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1321 |
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