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Targeting alterations in the RAF-MEK pathway

The MAPK pathway is one of the most commonly mutated oncogenic pathways in cancer. While RAS mutations are the most frequent MAPK alterations, less frequent alterations in downstream components of the pathway, including the RAF and MEK genes, offer promising therapeutic opportunities. In addition to...

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Bibliografiske detaljer
Udgivet i:Cancer Discov
Main Authors: Yaeger, Rona, Corcoran, Ryan B.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397699/
https://ncbi.nlm.nih.gov/pubmed/30770389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1321
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