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Combination of guanine arabinoside and Bcl‐2 inhibitor YC137 overcomes the cytarabine resistance in HL‐60 leukemia cell line

Cytarabine (ara‐C) is the key agent for treating acute myeloid leukemia. After being transported into leukemic cells, ara‐C is phosphorylated, by several enzymes including deoxycytidine kinase (dCK), to ara‐C triphosphate (ara‐CTP), an active metabolite, and then incorporated into DNA, thereby inhib...

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Bibliografische gegevens
Gepubliceerd in:Cancer Sci
Hoofdauteurs: Nishi, Rie, Yamauchi, Takahiro, Negoro, Eiju, Takemura, Haruyuki, Ueda, Takanori
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2013
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657161/
https://ncbi.nlm.nih.gov/pubmed/23320492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12103
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